# Can Cymbalta (duloxetine delayed-release) be crushed?

Canonical: [https://followyourswallow.com/medications/can-i-crush-duloxetine](https://followyourswallow.com/medications/can-i-crush-duloxetine)

## Direct answer

**NO. Do not crush.** Cymbalta is on the ISMP “Do Not Crush” list, and FDA labeling says do not chew or crush and do not open the capsule and sprinkle its contents on food or mix with liquids, because these actions might affect the enteric coating.

Formulation: Delayed-release (enteric-coated) capsule

## What to ask the pharmacist

Ask the pharmacist about Drizalma Sprinkle, a duloxetine product whose FDA label specifically allows opening and sprinkling on applesauce.

## Verification

- Source type: ISMP Do Not Crush guidance
- Source note: ISMP “Do Not Crush” list; FDA labeling: do not crush, chew, or sprinkle
- Source checked: 2026-06-10


## Safety

Confirm with your pharmacist before changing how any medication is taken. Match the exact drug, strength, dosage form, release mechanism, manufacturer or NDC, and imprint. A pill image alone is not enough.