Medication module
Can Wellbutrin XL (bupropion XL) be crushed?
Also searched as Wellbutrin XL · Extended-release tablet
Exact formulation checkedExtended-release tabletA different strength, suffix, coating, capsule, or manufacturer may have different instructions.
Why
FDA-submitted labeling says bupropion XL tablets must be swallowed whole and not crushed, divided, chewed, or cut. Damaging the extended-release tablet changes how quickly the medicine is released and can increase adverse-effect risk, including seizures.
What to ask the pharmacist instead
Ask the pharmacist or prescriber about a formulation or treatment plan that does not require swallowing an XL tablet whole.
Source checked2026-08-05
Clinical reviewSLP review in progress
Confirm with your pharmacist before changing how any medication is taken. This page never provides dosing guidance.
Confirm the pill before changing it
- Match the generic or brand name and strength on the prescription label.
- Match the exact formulation, especially ER, XR, XL, SR, CR, DR, or EC.
- Use the manufacturer or NDC and imprint as supporting identifiers, then confirm with the pharmacist.
Do not use color or shape alone. FDA guidance notes that approved generic pills can look different while containing the same medicine.
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