Medication module

carbidopa-levodopa extended-release

Sinemet CR, Rytary · Extended-release tablet (Sinemet CR) or capsule (Rytary)

Sinemet CR is on the ISMP “Do Not Crush” list as extended-release (the ISMP note indicates the scored tablet may be broken in half without affecting release, but not crushed). For Rytary, FDA labeling says do not chew, divide, or crush, though the capsule may be opened and the entire contents sprinkled on a small amount of applesauce and consumed immediately.

Ask the pharmacist which ER product you have and whether the label-approved option for it (halving a scored Sinemet CR tablet or the Rytary applesauce sprinkle method) applies.