Medication module
Can Depakote (divalproex delayed-release or extended-release tablets) be crushed?
Also searched as Depakote, Depakote ER · Delayed-release or extended-release tablet
Exact formulation checkedDelayed-release or extended-release tabletA different strength, suffix, coating, capsule, or manufacturer may have different instructions.
Why
FDA labeling says Depakote delayed-release and Depakote ER tablets must be swallowed whole and should not be crushed or chewed.
What to ask the pharmacist instead
Ask the pharmacist whether Depakote Sprinkle Capsules or another formulation is appropriate; the sprinkle product has its own exact administration instructions.
Source checked2026-08-05
Clinical reviewSLP review in progress
Confirm with your pharmacist before changing how any medication is taken. This page never provides dosing guidance.
Confirm the pill before changing it
- Match the generic or brand name and strength on the prescription label.
- Match the exact formulation, especially ER, XR, XL, SR, CR, DR, or EC.
- Use the manufacturer or NDC and imprint as supporting identifiers, then confirm with the pharmacist.
Do not use color or shape alone. FDA guidance notes that approved generic pills can look different while containing the same medicine.
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