Medication module
Can Depakote Sprinkle (divalproex sprinkle capsules) be crushed?
Also searched as Depakote Sprinkle · Delayed-release sprinkle capsule
Exact formulation checkedDelayed-release sprinkle capsuleA different strength, suffix, coating, capsule, or manufacturer may have different instructions.
Why
Do not crush or chew the capsule contents. FDA labeling allows the capsule to be opened and the entire contents sprinkled onto a small amount of soft food, then swallowed immediately without chewing.
What to ask the pharmacist instead
Ask the pharmacist to demonstrate the label-approved sprinkle method and confirm that this exact sprinkle-capsule formulation was dispensed.
Source checked2026-08-05
Clinical reviewSLP review in progress
Confirm with your pharmacist before changing how any medication is taken. This page never provides dosing guidance.
Confirm the pill before changing it
- Match the generic or brand name and strength on the prescription label.
- Match the exact formulation, especially ER, XR, XL, SR, CR, DR, or EC.
- Use the manufacturer or NDC and imprint as supporting identifiers, then confirm with the pharmacist.
Do not use color or shape alone. FDA guidance notes that approved generic pills can look different while containing the same medicine.
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