Follow Your Swallow

Medication module

Can Prilosec (omeprazole delayed-release) be crushed?

Also searched as Prilosec · Delayed-release capsule

CAUTION. Special handling

Exact formulation checkedDelayed-release capsuleA different strength, suffix, coating, capsule, or manufacturer may have different instructions.

Do not crush the granules. The coating protects the medicine from stomach acid. Per FDA labeling, the capsule may be opened and the intact granules sprinkled on applesauce and swallowed without chewing.

Confirm the sprinkle method and the right soft food with your pharmacist; an oral suspension also exists.

SourceFDA labeling (sprinkle administration)
Source checked2026-04-02
Clinical reviewSLP review in progress

Confirm with your pharmacist before changing how any medication is taken. This page never provides dosing guidance.

  1. Match the generic or brand name and strength on the prescription label.
  2. Match the exact formulation, especially ER, XR, XL, SR, CR, DR, or EC.
  3. Use the manufacturer or NDC and imprint as supporting identifiers, then confirm with the pharmacist.

Do not use color or shape alone. FDA guidance notes that approved generic pills can look different while containing the same medicine.