Medication module
Can Seroquel XR (quetiapine extended-release) be crushed?
Also searched as Seroquel XR · Extended-release tablet
Exact formulation checkedExtended-release tabletA different strength, suffix, coating, capsule, or manufacturer may have different instructions.
Why
FDA-submitted labeling says quetiapine extended-release tablets should be swallowed whole and must not be split, chewed, or crushed.
What to ask the pharmacist instead
Ask the pharmacist or prescriber whether a different formulation or medication plan is appropriate for someone who cannot swallow the XR tablet whole.
Source checked2026-08-05
Clinical reviewSLP review in progress
Confirm with your pharmacist before changing how any medication is taken. This page never provides dosing guidance.
Confirm the pill before changing it
- Match the generic or brand name and strength on the prescription label.
- Match the exact formulation, especially ER, XR, XL, SR, CR, DR, or EC.
- Use the manufacturer or NDC and imprint as supporting identifiers, then confirm with the pharmacist.
Do not use color or shape alone. FDA guidance notes that approved generic pills can look different while containing the same medicine.
Keep going